Nicole Mastrangelo Recognized by Influential Women in 2025
Her work goes far beyond simply filing patents—Nicole embeds herself directly into the scientific process. She attends laboratory meetings, engages with research teams, and develops IP strategies that protect discoveries from early research and development through late-stage clinical trials and market authorization. Her ability to translate complex legal principles into plain, actionable guidance ensures scientists are empowered to make informed decisions without being slowed down by legal jargon.
Nicole’s journey into IP law was shaped by her deep scientific roots. Trained as a neuroscientist, she first encountered legal frameworks while managing lab-animal studies under IACUC protocols. That experience opened her eyes to the critical role law plays in research ethics, compliance, and innovation. While many in her field pursue an MBA, Nicole chose a different path—earning a Master’s in Legal Studies from Northeastern University School of Law and later a Juris Doctor (JD) from Suffolk University Law School. This distinctive combination of scientific expertise and legal training uniquely positioned her to operate effectively in both worlds, translating the language of science into the strategic imperatives of law.
At the Broad Institute, Nicole’s portfolio is as diverse as the science it protects—ranging from chemical compounds and biologics to cutting-edge diagnostic assays. She works closely with scientists from the earliest stages of their research, identifying potential innovations and creating comprehensive worldwide patent prosecution strategies. Her proactive involvement means potential IP issues, such as premature disclosures, are avoided before they can cause harm. This “early intervention” approach has earned her the trust of the scientific teams she supports, who often regard her as an honorary member of their group.
Nicole also navigates one of the most challenging dynamics in research institutions: balancing the mission-driven goal of rapid publication with the strategic needs of intellectual property protection. Working with her team, she times continuation and divisional patent filings to align with both licensing opportunities and the Institute’s long-term scientific objectives.
In addition to her work at the Broad, Nicole is a part-time faculty member at Northeastern University School of Law, where she teaches an IP survey course for non-lawyers and IP & Technology to J.D. and L.L.M. candidates.. Her teaching style is rooted in clarity and accessibility, ensuring that students—whether scientists, young attorneys, or business professionals—leave with a firm grasp of complex IP concepts. She also draws on her experience teaching law students and advanced legal scholars to mentor young lawyers and business colleagues, passing along not just technical knowledge, but also the practical wisdom that comes from years of bridging two very different disciplines.
Nicole’s passion for education extends beyond academia. She serves on the board of A Girl You Might Know, an artist’s rights foundation dedicated to protecting creative works and empowering artists. This role reflects her belief that intellectual property rights are not just for scientists or corporations—they are for anyone with an idea worth protecting.
Nicole attributes her success to the example set by her parents, Greek immigrants who pursued the American dream through hard work and determination. They ran a family-owned pizza shop, pouring long hours into a business that allowed them to provide Nicole with an exceptional education. She recalls the many holidays and birthdays she missed while in school or working, but her parents’ unwavering belief in her abilities—and their constant encouragement to pursue her goals—gave her both the confidence and resilience to thrive. “They instilled in me a strong work ethic and the belief that no opportunity is out of reach,” she says.
She is candid about the challenges of working in a male-dominated field, particularly one that fuses STEM expertise with legal authority. Her advice to young women entering this space is direct: always maintain your voice. You are your strongest advocate. Don’t wait for permission to join the conversation—ensure you’re at the table, even if you don’t fit the mold. Nicole emphasizes that passivity can lead to missed opportunities, and that speaking up consistently is essential to making an impact and being recognized for one’s contributions.
Honesty, integrity, professionalism, and authenticity form the foundation of her work and personal life. She believes a person is only as good as their word, and the trust built on that principle is invaluable. Her commitment to these values has sometimes meant resisting pressure to conform to expectations that conflict with her authentic self. For Nicole, staying true to her beliefs isn’t just a matter of personal comfort—it’s a professional imperative that strengthens relationships and enhances the quality of her work.
Nicole’s role at the Broad Institute positions her at the forefront of scientific innovation, and her influence will only grow as the worlds of science, technology, and law continue to intertwine. Whether she’s drafting a complex international patent, mentoring the next generation of IP professionals, or advocating for creators’ rights, her goal remains constant: to protect and empower those who push the boundaries of knowledge and creativity. Her story is one of adaptability, determination, and a rare ability to excel in two fields that demand very different skill sets. Nicole Mastrangelo has proven that scientific precision and legal strategy are not opposing forces—they are, in the right hands, powerful allies.
Learn More about Nicole Mastrangelo:
Through her Influential Women profile, https://influentialwomen.com/profile/nicole-mastrangelo
Influential Women
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